When fasting (meaning, in this case, not eating any carbohydrates), the pancreas releases a polypeptide hormone, glucagon, that stimulates gluconeogenesis in the liver (1). Glucagon functions via a regulating bifunctional enzyme (1). The enzyme dephosphorylated acts as phophofructokinase-2 (PFK-2) and glucagon induces phosphorylation to produce fructose bisphosphatase-2 (FBPase-2) (1). The
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